College Football Odds, Picks, Predictions, Best Bet for Week 4, 2022: Proven Simulation Like USC, Texas


No. 5 Clemson Saturday afternoon at No. 21 will face its first real test of the season when it travels to Wake Forest. The Tigers have won all three of their games by at least 20 points, while Wake Forest is coming off back-to-back wins against Vanderbilt and Liberty. Caesars Sportsbook has Clemson priced as a 7-point favorite in the latest Week 4 college football odds. Want to support the Tigers with your Week 4 college football bet?

Another great Week 4 college football matchup is the 3:30pm ET SEC on CBS matchup of No. 20 Florida vs. Tennessee No. Facing 11 The Vols have never been favored by more than a touchdown against the Gators, but they are a 10.5-point favorite in the latest Week 4 college football spreads. Before locking in any Week 4 college football picks on those games or others, be sure Check out the latest college football predictions from SportsLine’s advanced computer model.

The SportsLine projection model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated more than $3,300 in profits for $100 players at its highest rating. College football picks Against the spread. It enters Week 4 of the 2022 college football season at 51-43, the top-rated college football spread among all pre-2021 money-line picks. Anyone who has followed this has received great income.

Now, it has turned its attention to the recent Week 4 College Football Odds Lock in picks from Caesars and every FBS matchup. Go here to see each selection.

The best college football predictions for Week 4

A college selects more sample in 4th week: no. 22 Texas (-7) goes on the road against Texas Tech in a 3:30pm ET matchup in Lubbock. The Longhorns have had a roller coaster past two weeks, but they’ve come away with positives from both games. They nearly pulled off an improbable upset against top-ranked Alabama two weeks ago, easily snapping a 21-point spread.


Texas looked like it was going to fall victim to a trap game last week as UTSA took a 17-7 lead in the second quarter. The Longhorns scored 34 of the next 37 points in a 41-20 victory, covering the spread as a 13-point favorite. Junior running back Bijon Robinson rushed for 183 yards and three touchdowns against UTSA, averaging 9.2 yards per carry.

Robinson faces a Texas Tech defense that is coming off consecutive games against ranked opponents, allowing at least 27 points in both contests. SportsLine’s model has Robinson rushing for more than 110 yards and a touchdown Saturday afternoon, which is one reason Texas covered the spread in nearly 60% of simulations.

Another of the model’s college football picks: No. 7 USC (-6) goes on the road against Oregon State in Corvallis at 9:30pm ET. USC’s offense is already clicking on all cylinders, scoring 40-plus points in all three of its games this season. The Trojans are led by sophomore quarterback Caleb Williams, who completed 74.4% of his passes for 874 yards and eight touchdowns.

Oregon State’s defense was shaky at times early in the year, giving up 28 points to Montana State and 32 to Fresno State. The Beavers will have trouble matching the pace of the Trojans on Saturday night. SportsLine’s model expects another big day from Williams, as he’s throwing for over 320 yards and three touchdowns in recent simulations.

Oregon State quarterback Chance Nolan hasn’t had nearly as much success in simulations, completing 16 of 26 passes for less than 240 yards. The Trojans are one of the strongest picks of the week, covering the spread in more than 70% of simulations. Check out other teams the model likes here.

How to make college football picks for Week 4

The model calls for who wins and reigns in every other FBS matchup in Week 4, and it says the top 25 favorites will drop sharply in one of the biggest games of the week. You can only get every pick for every sport on SportsLine.

So what college football picks can you make with confidence? And which top 25 favorites are the hardest? Check out the latest college football odds below Visit SportsLine to see which teams are winning and controlling the spread, all from a proven computer model that has generated more than $3,300 in profits over the past six-plus seasons.And find out.

College football odds for Week 4 (via Caesars)

Check out the full Week 4 college football picks, odds, and predictions here

Friday, September 23

Virginia at Syracuse (-10, 53)

Special game | Syracuse Orange vs. Virginia Cavaliers

Nevada at Air Force (-24, 46.5)

Special game | Air Force Falcons vs. Nevada Wolf Pack

Boise State (+16, 45.5) at UTEP

Special game | UTEP Miners vs. Boise State Broncos

Saturday, September 24

Kent State at Georgia (-45, 62)

Maryland at Michigan (-17, 64.5)

Special game | Michigan Wolverines vs. Maryland Terrapins

Central Michigan at Penn State (-28, 63.5)

Special game | Penn State Nittany Lions vs. Central Michigan Chippewas

Duke at Kansas (-7, 65.5)

Special game | Kansas Jayhawks vs. Duke Blue Devils

Clemson at Wake Forest (+7, 55.5)

Special game | Wake Forest Demon Deacons vs. Clemson Tigers

Baylor at Iowa State (-2.5, 45.5)

Special game | Iowa State Cyclones vs. Baylor Bears

Florida at Tennessee (-10.5, 62.5)

Special game | Tennessee Volunteers vs. Florida Gators

Notre Dame at North Carolina (-1.5, 55)

Special game | North Carolina Tar Heels vs Notre Dame Fighting Irish

Texas Texas Tech (+7, 61)

Special game | Texas Tech Red Raiders vs. Texas Longhorns

Tulsa at Ole Miss (-21.5, 65.5)

Special game | Ole Miss Rebels vs Tulsa Golden Hurricane

Oregon (+6.5, 57.5) at Washington State

Special game | Washington State Cougars vs. Oregon Ducks

Northern Illinois at Kentucky (-26.5, 53)

Special game | Kentucky Wildcats vs. Northern Illinois Huskies

Arkansas at Texas A&M (-2, 48.5)

Special game | Texas A&M Aggies vs. Arkansas Razorbacks

Wisconsin at Ohio State (-19, 57)

Special game | Ohio State Buckeyes vs. Wisconsin Badgers

Vanderbilt at Alabama (-40.5, 59)

Kansas State at Oklahoma (-12.5, 53)

Special game | Oklahoma Sooners vs. Kansas State Wildcats

USC (+6, 70.5) at Oregon State

Special game | Oregon State Beavers vs. USC Trojans

Utah (+15.5, 54) at Arizona State

Special game | Arizona State Sun Devils vs. Utah Utes

Stanford at Washington (-13.5, 63.5)

Special game | Washington Huskies vs. Stanford Cardinal



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